For example: You might experience the return of Covid symptoms, but rebound cases are typically very mild. Scott Roberts, an assistant professor of infectious diseases at Yale School of Medicine. The benefits of the drug far outweigh the downsides of rebound cases, says Dr. Should I still take Paxlovid if I'm eligible? You should also wear a mask for 10 days after rebound symptoms begin, the CDC advises. The CDC advises isolating for at least five more days before checking the agency's current isolation guidelines. If you experience a rebound case, you do need to reenter quarantine until you test negative again. "That's getting too far out over your skis without the clinical research to guide it." "We don't know if it's safe or efficacious to do double the amount of time of Paxlovid, doing two courses," Smith tells CNBC Make It. But there's no clinical data to back that up yet, he says. Davey Smith, the study's senior author and an infectious disease specialist at UCSD Health, hypothesizes that some people may metabolize Paxlovid more quickly, or that the drug might need to be taken for more than five days to fully clear the virus in every patient. In that scenario, Paxlovid stops the virus in its tracks for five days, but doesn't stick around long enough to purge the infection entirely - allowing the virus to temporarily replicate again once the drug is gone.ĭr. Patients also appear to recover from rebound cases without any additional Covid treatment, the CDC says.Ī UC San Diego School of Medicine study released in June identified "insufficient drug exposure" as the most likely cause. They appear to be very mild: A June CDC study found that less than 1% of patients taking Paxlovid were admitted to the hospital or emergency department for Covid in the five to 15 days after they finished the treatment. Ashish Jha said at a news conference last month. Roughly 5% of the tens of thousands of Paxlovid users have experienced rebound cases so far, White House Covid response coordinator Dr. Some people who take Paxlovid test negative for Covid after finishing their five-day treatment, but then test positive or experience symptoms again two to eight days later, according to the Centers for Disease Control and Prevention.
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